Introduction Anterior Maxillary Osteotomy (AMO) is one of the commonly done orthognathic surgical procedure in maxilla. Though a lot of research have been done in the Caucasian population regarding soft tissue changes after AMO, there are only few studies for the southern Dravidian poplation. The purpose of this study was to evaluate the soft tissue changes in association with AMO setback in the southern Dravidian population Materials and methods The study included a series of 10 patients of age group 20–40 years who underwent AMO. Lateral cephalograms were taken for each patient 2 weeks before and 6 months after the surgery. Three parameters namely, nasolabial angle, upper lip protrusion and interlabial gap were used to evaluate the soft tissue changes. Results Mean values of pre and post-surgery were taken for nasolabial angle, upper lip protrusion and interlabial gap and were compared. Soft tissue changes in all the three parameters were found to be statistically significant. Conclusions From the limited evidence of the study, it can be concluded that soft tissue changes following AMO setback in southern Dravidian population and the Caucasian population are almost similar.